Endocrine Abstracts

Introduction: Ataxia telangiectasia (AT) is a rare, genetic, primary immune deficiency disease characterised by immunodeficiency and neurological manifestations, with increased tendency to infection, malignancy, and autoimmune diseases. Both growth delay and endocrine abnormalities are occasionally reported in these patients.Aim: To study linear growth in relation to endocrine and immune functions in a cohort of children with AT.Pa...

Vitamin D deficiency causes rickets in children and osteomalacia in adolescents. Rickets cases are still being reported in the Arab gulf area and worldwide. The clinical spectrum ranges from subclinical (asymptomatic) form to severe symptoms and signs including progressive bone pains, myopathy, waddling gait and bone deformities.We recorded the clinical, biochemical and radiological data 50 adolescents with severe vitamin D deficiency. Clinical symptoms ...

We assessed glycemic status using oral glucose tolerance, 72-h continuous blood glucose concentrations by CGMS, calculate HOMA and QUICKI indices.Population: 15 adolescents with β thalassemia major.Results: Oral glucose tolerance test (OGTT) In the 15 thalassemic adolescents (age=19.75±3.08 years) showed that four had impaired fasting blood glucose level (IFG)>5.6 mmol/l. One of them had diabetes (BG=16.2 mmol/l at 2-...

We studied the growth data and bone maturation of 45 CH children (25 girls, 20 boys) with CH, diagnosed through the national screening program in Qatar, for 6 years or more to examine the effects of initial T4 dosage (50 μg/day) with adjustment of T4 dose to maintain serum fT4 concentrations within the upper quartile of normal range and TSH<4 mIU/ml. Birth weight, length and head circumference of patients (3.21±0.43 kg, 50.5±...

Introduction: We evaluated glycemia and the iron status in patients with NT-SCD and 6 patients with TD- SCD by measuring serum ferritin level (SF), liver iron content (LIC), alanine transferase (ALT) and fasting blood glucose (FBG) over 5 years of follow up.Results: At the initial assessment, 16 adults with (age: 33±14 years), and six of TD-SCD (n=6, age =25±10 years) were studied. 6/16 of NT-SCD had SF > 500 μg/l, and 5/16 ha...

Chronic administration of L thyroxine to children with hypothyroidism may affect cardiovascular dynamics.Aim of the study: We measured the BP and heart rate (HR) of 25 randomly selected children with hypothyroidism in relation to their serum free T4, and TSH levels and thyroxine dose mg/kg. Methods: 25 randomly selected children with a mean age 9.6 +/- 4.5 years with the diagnosis of congenital or acquired hypothyroidism. They were...

Introduction: Ataxia telangiectsia (AT) is a rare, genetic, primary immune deficiency disease characterized by immunodeficiency and neurological manifestations, with predisposition for infections, cancers, and autoimmune diseases. This case illustrates the affection of endocrine system in the form of hypothyroidism and hyper-gonadotrophic hypogonadism.Case Report: A 14-year-old girl presented to our clinics at Hamad General Hospital, with history of prog...

Introduction: Growth failure is the most frequent endocrine abnormality observed in patients with sickle-cell disease SCD. Decreased synthesis of IGF1 might be secondary to a disturbed GH–IGF1 axis and defective GH secretion has been reported in some patients. Infarction, atrophy, and hemorrhage may occur in the pituitary gland in SCD during or following the vaso-occlusive crisis.Objective: To define the possible abnormalities of pituitary gland in ...

Introduction: In patients with β thalassemia major (TM) The interplay between liver siderosis and hepatitis C virus (HCV) infection may facilitates the progression to insulin resistance (IR) and diabetes mellitus (DM).Objectives: Many TM patients are infected with either HCV. Therefore, we aimed to explore if there is any association between DM and HCV-RNA positivity with different genotypes.Patients and methods: 148 TM patien...

GHD in adults (AGHD) is a clinical syndrome associated with lack of positive well-being, depressed mood, feelings of social isolation, decreased energy, alterations in body composition with reduced bone and muscle mass, diminished exercise performance, and cardiac capacity. These manifestations are also common in adults with beta-thalassemia major (BTM). Performing provocative testing in all patients is cumbersome and expensive. Many studies suggested that IGF1 may be used for...